	   SnapGene      LGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCACTAGTCCAGTGTGGTGGAATTCTAGGTTCTGTCCTTCTGTCCCCAGCACCACTTAAACTGGGTGTGGTGAGGTGGACCTACAATCTCAGACTCCAGAGTAGAGGCAGGAAGAATTGGTCCATTCAGAAACCACCTCCACTGTGTGAGACCCTGCCTGGGATTATAGACAGGCAGACAAACAGGCCTCCTCCCGATCTCACTTTCCTCTTTCTCTCCCATAGGTGCTACACTCCGATCCCACCTGCTGTCCCCTCACTGTGCCTCGGCCGGCTGGGGTTCCTGGGGATGGGATTTGATGCCAGTCACAAATCACATTGCCAGGGATTTCCAACTGACCCTGTGCCCTGCCTTGGGGCCTCGTGTTGCCAAGGACGTTTATCTTGGGTGCTGGGTGACAGAGAAGCCCAGCATGACCACTGGCCTGTGGAGCAGGGCTTAGCTGCTTGTGAGCAAGGTCTACAGCAAAGTCGTGTTCACAGTGGCTAAGTTCCGCCCCCTGGACCCCATCTCCCCAGGCCGCTGCCGCCCACCCTGCTCTGCATCTGCCTCTCCCTGGGCTCCGCCTCCTGTGCCTACTGAGCTGACTCGAGTCTAGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTCGACGGATCGGGAGATCTCCCGATCCCCTATGGT  4™                                               +                                                                                        !                           "            (      "   *            %            #                              "                        /                     
                                                      !                                 
                     "         #            !                        *                                             	                                    '   "         !   $                                                                                	               #   +            #                                       %         $                               "      (         
   -   %            #               '      (         ñ y–Ÿå‡ˆ‰Ž“¢£Äòûü ¡Ê
r5rô²î  yzœ¸úN" ¥Æ¤­Åq
QVj×õR€ÿ×§F±~2 – ò �Á—Š�ý&®àÍx
Ès³XÆ · `ææ5°Ú”Ïó¢ó“
Ë
'fs6Ã•G«ï† C “�ûO/¥ê	ö	
|
�¨3 •ð6]®äD¼Ó	RžÊüS2¸ 5ÃGàg� f{#¡¦Ç¨Ær)
;
A
\
xn±ãöå¾’Øó²ÿÙ- z¹Ï÷x™2W&ÑÝkØš  �D÷’ÂÇÌb:w‹�Ì',áÎ	y
ï
›É‰/ØîŒhY $žåêsþ)Óè"x’·ÍAbŸ — Lmž˜/¯çŠh
Ó
t¿-r‰ðh´é(Ç F ó þùK[¾¾5´ß;ö  œ açîá#Ì
(g¶Yi�Î³†–ÌåKŒ«ÕÄ�¦ð‡ o ®õR©ì/•¼Äë3	”
	tªPZ„.k+ t 40\’6f±ÐØô‡£ß'	¢	í	ÿ	�
‰
¤
½
\¨¹Ì7RÄéÄßÆYHü¬á¤ ¸ +ì;Žç(ˆÛô‚¿	Å	ù	p
¥Àt"-?ñ¸ D üÊêØ[¦ß½	Ã	è	ë	÷	?

l„‡ËX© P5
}
—ž‚åÑ�4 M ”žåÑr\‡á<1OÇk— X y0EÇ•Õ	
ôø-ÿf­÷"ÏjÇ\Õ ˆ ñ7¯ï7	à	LSj	*üý¹é%›H	h¹ 8^åÔ	™çŸy»ÓT�6ŠÈáó�ð ‹ –ô¯½÷
’Ëoûƒ€˜å  éES
û
E3T	ÄÉ  ° G¢¬Çä<
Y
­
¬„äW ½ g ó¤æ™¢É³Ú Ï |$§È©µÛhs|šO
]
²8 ¦¿Ùçè €Foí*
/
B
yÇ!oç÷K“ž¦ô i¾Ðþ 5.6> Q]†Ùâ“Ýø$@'fYŠÙgz¹$* } É +3š²7
�
Þ–—@Š Ö {rºCÞÌ÷3¦	�
Xºl°›œ‰d y 8CRÐÓ!y0>Ìâ
æ
ÜzÒ~‚¡ÕfÓ“  ‘dø�“ÅÍ-dŒ‘Í*-ñ0ºÑ	z
œ¾ÌpŠìïÁŠ EÈC<âæ	xñÑ VbiZ < > »ñŽÃí[x(ÁÃÏ	¶
ÊÏ0L”�ˆ R c‡Ù¾û%;»ð
:m ^ÄNÙ¿ÝÔ) O ëçtîã	2ÒBc–U å %mŸæÊ¶	é8y“¸3QS + `–½-ÿò:	
�*‡—�Ô#Î) Šé 	 ³ ²Ë#Vótþm @ Æ ïCæÀm7E>‚@ruÚ™• " ˜ Û 0‹É.Ùñ,ÒD`Éê)È Ÿ Mn ¤cûàF
ÐsÈŠN®iqg›R! û dŸ™]l€°è%:‹	i
¸
Ô
+J^uÂÐ+9]ãwXµç G ÇXužO[¿6‘˜' ô T‰Ü3–³z‘Å	S	Á
Ý
F�¿ƒà�Gy© …ÿLÓn\“‚µ<n5Î ‰¤¬ú|IØ 	`	ë
wí‰÷ JkèÊâ!$O´·Ïhò}‡ÊÑæÖfçŽ× V ® ­håöj‚	ˆÍ�ÉgÏÅ‘ñˆ � Ä bïa:)ä´5ŽCL¬§P T ¤ 	5OWÅ
Í
2<Z\@ð:{—¸Æ	m…k¼" ¯ S	í02–¹7èì0	4	º	e
Ç
 
4u=!
«®Äy|‡/Æ Z p àGSžö	>	W	
¯:'QuÄñmß^lv  „ ö di½ûÿC	G	K
½ï/^B@We gl…7=¼   ª³Åa
•
úP[2+
( J ¦ 5Yy“<ŒÉêÁï—£	¥
¾
7]©ºÅùàÿÅdµÇHDIj"_Á	 e 9]egB×	‚
Š
`ÍÖê©$ÛýK~" 8 u ‘ © )1o7?Ùfˆ½î	 

t
Ã‹©"Å$¯G¡ÞM­¥Z*  1 {›²Ñõ]–¤à(	
¨
<Ž8S2à<™©ºÚZ}¼È=E¼Úâ”¯îœÖ  �‰�„yÀ	Æ	q
°
³
o”B�¦Á/¯Üù@Û 	Cs ' ¹ rÆ¯Âò=K{õ>N–`u#.¤±(ü\xL¾ 0ñ<‰àè)¦·Àòý'ƒÉ	Ï	ú	‡GQ²ñoò…*% ,<J¦ÏíýÕÛq’ÜQYûe	q	z	†	�	›	Ï
ò
Ôb�C_b¹¢ • xMÅ4Ù¡ú­ßpÌÉ
U4 Öª}…Åÿ ïö\˜§é	:
@
wmÜ1™½‘òþf E ý�ËaJ9v	g
¾ˆ!4Ì# n s › íë.:‡»àÞê&	2	¾	Ä	ì	ø	þ	€
QX…ä!,>XªÔYƒÃj äé×¼	4
~
,þ¬ƒ†Æà;N Š óèî6	ß	˜ú‰š‚Èï ¼ X
Ÿ£~�æÿ˜çV5 QÝ*2±6
œ
á
–Ò Q º�cºð/å	lëÀU¾‡Ó  * N ä l•±Ê"Uæsñ9	â	œ(2PTl ! Ú ú ŸkÈŠ	]l*â+=C�W_fÈ˜ 2„ˆ²WÒ×
		R	_	N‚ˆ4x j`9NVÄ
Näõã?g‡ïÐÈefæOÖ" Y ²1FR�¸çú	/	B	V	ù.9?Vÿ&k­Ãx{ð1Å<]» d Xnz;Èî•–Ö	

6 #¨®Ä#cÙ»CDJ®í & ñAøa°'ûÿ m r õI8 oTW½ã +=�ÕñÂýi|„ ‰ ò°ç3
W
à
+ý¢•:™œU ¹ÉƒVjÖð	8	á	k›�ê'S
wÒ % c Wm”ùA	
Mã
†8UþºB&wIåº UæÕø	@	

š¼7Tâ*<¡9�ð&äÑ{/ \ ¯ÂVÒÓÔŽ��¢£
	
 ):;st78‹Œ�ŽÉîïáâãÐâô`anxyzñò ] 'è°Ãâ9¸W_›‘¤¡z3GPÔu	o‘óû ¡g¼6äÕ?è{U�SWÊ5öãõb÷ (ZŒßé]™ÄãX’¾ø
±¢{*„lJÆp’æ á Wu>Sµ,“4<Qëóc„¬¶�™°ôü ^ € ë :—õ`¥°´	N	ª	HÕæ1
<;  Œ ç ±×¹œ 
Ì¸püv!Q
 @oµªxÅo»ä j Ì7FIŸT
™
éðº
Tcø ¢Ïh½ÏÖ@k	€	ü
F|'{öË6œ Êö1 !åêP	Y	‘V4‘U�X÷s  
)�êB^šä£Öå 	Z
¦™£+¼¢&,F † [àY“=
M
�
ù
|¹åmã/ÇÎÓ ± bÅ¿…‘ÐØ“ç  ÄûH­¿Èôý<	E	¸	®
­²`…ýKJXŒq  â ÿ jvhK(_¶-]	á=ÂVd…Ãý XTm(5RŸšô9´‚õ ¾ Â
”ô+-±ß À ?¿™óì¥ç£Ê­·š Û � Ì Ó NƒÖ�Úö¿akª‡P
^
cöÖ2’={Ý¶Ë Ð Þ ì ÷ ø/<;%Ü±	O	.iÀ€è9³ _ ˜}¨É¶it}›¦«	´	#
¡IYÚré¾áë ˜þ}‚`µ”	Ú	…
Ø³9§gçª<| 65f�øC
¡
ìñ·,DNÍqw¡‡ÿ/ è ¶¿Z²ºî0
£1–Ù™B�Ž¹ÖýnëRí¿ÚÂ!  - � 'ØGÿ¢V	I	+
z„"pø‰%”§õ"aj´6?7 �pu	
ŸÈèÜôtLŸ{&0ÑO? µ ï "œãw¶õÂ%g'îú°¥¯�+ AA"(ZœõhRšÆ ¼ R^‡Ú+”ù~ì#AüÐpå% Â pÍÞ3«c
Á‹Úy{ƒºØ’ ,8Pa›8
š
ø—»ÞA�d  h k ~ ÍÕ4¶³G U
—
ž
1ENäîqUù Ê ´%X½êßñ,ÌÁÝ hEJì˜ ‹ £&-¾„Ð%ÄøFA�
ý
IYG»b@­§´4De2
 × H…§	œ|÷� |ª»i¸LG×�7!ËF  sÐDßjÍ@4Ll	�	 m}(±ÞÌŠ"o÷%œ¢ z 9v?ã
Ó¬›5âg\ÌÞ”¹ ?¬µ"ë	Z	Ýàƒ§YG±øtL 	Ñ	uÇç
‰Ð’¢Wé/û]  D‹"SÔz–æ1ÍQ{í’ÖVŽÔ!-" Ž_›åùÀ!•ž¤ä
¯†�’¬ÃÎñòw
’
eÇqÂ”FW B ’e”Î.w51C»Ò	õ	[
{
%�°â·Âß Cr‘Æø+.æ‰š,q½¶í@aÞ:‹ž'gG# *3­ëôQ¨/['e×¡	[§€¤¿Íè²J‹©ð·£- L ÉDÆZqÞ”Ô	ç	>
e!†ä0Wj€[Ô ‡ R
ö
ú
KûºÒnè$—¸ä  Î F«ìÚãÿg™.
N
¬
«Æ òæJ¥ÈÏ4! x È Õ 7P\…Øáq’ÜÒ Ë/=¥	Ž
yX}¯f¸?ˆc# ; = �Ä†Ø,B½ú)¹ÀÂÐ	9½ËoÎÐKMÜa ² ¼ò
†–1Ñ•‰è ? c£î\9·
IÇØÏp?tÙ” Æ£«{HmyÄÀ
Ü
ê
E€v’ZìmŽFÍ S £ IÉ1³49�·ÉÅlj� ƒ Ÿcõþ=	F	¹	
`
ÿ
®¼ dfOtÃÞ6*  0 7 � ¨ (dx>šÀ¼§
;_�Šø!þGÚ!LÀ}Y›Õ*  ¥Åüˆ®ÁÚßñŽ¥¿ü&<JxÎ	¯
ñ
n“Óa†Ž•B_Ú„BwK¡r ” š wìLœ`uù¬ÞËý	W 3Óþ è)Ö«þ—Mî   P Ù ã ù k1‡¹ï.		Q	^	ä	k€Ve†  i_:·Uâ>§ÃÂCdìÄ $ b lin”ÔRTƒ & çf»ãUš�6S
9 %4õÏö à æ Y=R+³©	)·0kêP;b:µ nËž©j		&z¹õ› 	aÃúÕó;	·	Œ
¸Ï.¡+‹E ¿ J'l
'˜ž*, Ò Ý —Õ.;�_†³	Ù	„
bõ‘q8²µÊàê , ¾4þ U
ž•Ø+Mˆ�ÛÕó$s~ ê`ì%Á ´ Á î !›Ì*ô@2ÁÀ&ôíù‚¯Ÿ¤® 
 g ³$WÔgOD0Ýÿ€ËÜ	 ,ÃÿCnE›¡ >uÏìš¦áè.F°Ë¸ A ¬P§q÷ã«ˆô	v
dçÁ±“?Ý9�Þ w Ç Í Ô O„×p‘Ûª.ÙfQ
ÅW…çI¤–·ã : ¢Al8
Û
Dnu×o>sÛÌ ‚ ¢ ÀðbIw
_
0Œ�÷38ŒFsƒAiv|š  “ ™ ø 09«¸ÝÊ	P	Áëí # a ß <ekºâ*Œ�¨²/jÓO:aÎ Ñ Ü ù3&ýk²	¶	&ŒÚòrŸéë$*´ÀÉ í  š=+1À%/à-�E¯ÊBD ¡ Oo¡¦©evó	
Ú
t‹nr£Ühœâ ` ™düáª·¿)jœ§±	µ	$ê#ÍC¿ì'   N¥	
du¬	­	®	¯	°	ð	ñ	ò	
$
Ø
Ù
«ÑZ[\]OPjklmªÛ\Bª«" ~~½NUÊMbhuŠ~%
G
¬¢ÒJ^ÉIQ¯ô«s]HS¬ « c�&
H
†
ÙK:v£Ç	Ãü,:2tYóë ü ÿ^é´K_^øx§«9I­! ™ ¨V ~ƒÛiv&a¶•	j
Õ
­JT_bµhõä¬=^}èT$ e¾OšËm*Nlq‹±;Œ	Û	¹
,¨ÓÊèJ�£R°Ñ¶¦ }ŒžY€'
‡
¢
ÈPr¼Äý-3ôì0 6ÏõÊ>Úò¸w¤Ÿx( ÈëYD
svÎ\ÀÂ7€u’ˆ–™ ' H ¬ 7gdy‚ùI
í:L-;EO
§³;¢Z  Û ïÆ	T	Â
2Ú×þ„(_¾Sdî¬:Ã é UŠ·Ý[—³’N	L	1
Þ
U‚à—ìÀqªû® õ ý À4{‚¤—µû�ºÀáy¨$HzØÛžÑ uFJ‚´»_êG‡šCL`â*>«ÜoÎùÜ� J    . Ž ¡©�£o„Ü·Ì	Ò	,
ª
#®co”¶=kµ_~U ( šMÔÓ÷˜]K¶i¥­#o6 S j'6bÖ
U`Š›ƒåG¨ö@žé7@¤  †ÙHWY€©wW	J	–	k
{…qùÊö&•b>ùÏ8 Òln´²n	ƒ	�	˜	m
º
ì
ÉÔÝž\ÒîuM'±ûP €€ˆ¿‚ŠáûÌ <Ü	 
 ©ìxéKõS?Š|ä-1 ¥?P›º+JO_r-}�éË¤Ì ðø§  3 f­B[q}‚«BmŒ¦Ùâ!	*	a	v	
4±¾øŒ·Ò:@ ¶ ð x·%Ÿ
&PqiÖóQ~þ±¦E°í1 ~ã(
ÐÉûä4ŽØ, #�äKléöËZÒ
î
(ˆ½Òçï.w‘×g³èõ �‘"†Ã�o
ˆ
£
¼
µ¸ËhÃÞsÅËûOà�¥ W xÐÂ	–ó÷k[�öÎiÊÐÆ– 7®iæ)D‘
xŽSÇò ¯ En´{ƒ7¥h¡½ý= | BBöËå
#?Ûe¹�‰ y•Ôe›’‰) cðìZ$;µ
wð]Ã“‰(	 _,Éíýµ�7R ž Å búß$E
*BåÏ6ÁDM­8\ÑvqšæQ SˆÛ•�t���—¨& U ­ Ã  4¬;[ñz|B„Î»  ßh6J
d
Æ
3î]<A	†lu	# I ¥ 8‹éA\es
Â¨Õ1ß;F˜ ¨´¹|ÇÝ
<i^»Ù“+ /;IqÎðÔp‘¶
PXzƒúd	p	y	…	�	š	È	²
Î
=M.FPŒ®±Û^ðn£)[½ î-9Ä3†—ºÝé	%	1	9
f
È
v3PÛÿ0˜©¼‚eÄ » 
Üã1í5	»	Þ	›
ù…Åß}ˆæÇ  ) ° !TŒ±bÇ‰	M)*¿BT½3^# ±Qð
œí8Mæ	.	U	Ã
5@>î"bØ%`¬¯zeïúþ­0;N l q ¸È‚VôHŸ“2
V
ß
âV…€Av˜Ávü [ ®Áá5·TÑ>¡÷?	
2FOzá(rRVíà_mwú   ê Vt‹Þ\˜Ö´	M	Ÿ
°;ƒå IÅò«¯ i ?´ÎÎHO	X	˜
�ïwŒnºr0 … A¾üD	Ÿ	L
¥_~˜ü�»âÍ×%IÒ  þ iÁ^\	¾àÁòU~8ÂŸÞ Ë ö M‚÷�Ùý¾j|“	"
×Xf-hz©{Ü½ µ&5Y~¡e÷ 	H	t	ƒ¢ëð0¶C˜A€mz³/†NÙ> v}ë"b
!û›Q™Ï×‘Œ µ¼`–
DMãëí+÷pÀ  ©%G„·Kiƒ$?EFKHa?¬Ý¦³!3$ Š«´t•Æˆß«[ú\Ý,K% 2ó.Z¿ ”�	&v®4…ÂðB‘
Z$¯Æpá I¶E¨µ`¶fV  K 6ÑÅÊëpÝþ˜¤	Ó	-
«
õ
Jªúd®e#·>‡3" ¢ªz…×+¼ùG¸¿
é
8H¼•ÆÍYÎëJlE`
$  / 6 � § ¤'wÞ=�™ž¤Í	¦
þ
^’»Ò‰”cAe¶ÈÙk Â5 Ø ^†›ÕøTü	j¦ªýL hQ™i	~	¨	%ô$ Ô:I€ÔT^…Ø	ƒ
‹
a×L·�}_p7D f )ÓfNÂCÎëÜøþ®ž 9 v «pâ@-HØ7
u
/‹ÄŒV°„æH8Ÿ ’ *2j¹8%‹ßqžN®A  }¼MTLagt‰©¾(cï	
×
ª#Hó¢©"[ÌAG© ª §ÿ)ÚkpISa´Æœ¢û1÷¦òê8¥ |‹êÎôxÉX=9r¦²»Á•&"  tEÚI�M	K	†Tú~á)=ªÛß~'–½ÍcÛ#p×ú�Ð   RXœ¨Òö—5Ë	Ñ	©
n¤šÉF?�ø£( 2 ‡Ñà>AZk�ª³¹A^¥á)	m	‚	—	
l
|�3ë[½Ë÷>‹ã,°ïú9 �…
n
»
Ñ
í
pÊÂÕÝúãv�NßD²¤ { wDm³zÁ	ä
•Cd�6€”Ód
ü•<
 Þ#�´
ïœ6[�Q-  .:HïÓoŠ�µè@[c	o	x	„	Ž	™	Ç	r
±
§Ô0­°ÞEŸA]Üïh]Í(ºt% ( º ÿ‹°â°Ã…	ìLÜå	$	-	ˆ	Ý	?OíLa$/¨)¼åùý2]M >sÇ�­ÀUÍóÐ=á„�yv@‹H¹u/ Lh�@ŽØü]}ö[	s	’	ž	!
¡Ö}—T}².yÖM ¨‰$ƒ¶s#”>D|! Þªêö¥²ZÖ¿## 5 1òvœÖÝ*u˜­»3ýè
ô
~‘Ñˆ“ÌXdµÍØê†! ÓÒÁPSS„h	}	û	óü^C 
¦áþ(,K`os¨.ŠHR³òúp0¡ñ¨ 
=@Q€Šé§¸óÈÊ	Ð	ê£¥À+ù -GîCÝç"ZŽb	w	
Ð
cî5D“Zc�Ž£;' =Kg§þ�×#T¯\r|„“CÏÛä#	,	r	‡	‘	�	Õ|Ž»Õ¸Õ". 4 ÒÕÜt—¬2Rn§üRg	|	ó
c´¿×ùB( EFÐÑŒÖ®~rs{ƒ !�ÎÚã"	+	f	{	œ	`ab²³WXY�ºÓÔA  -ì  ›GACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GCACNNNNNNGTTSAACNNNNNNGTGC,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNNNNTTYG,CRAANNNNNNGTC,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,TCGGTC,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,TTSAA,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GCTCC,GGAGC,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,CCDG,CHGG,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                                       (                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     	                                                                                                                                                                                                                                         "                                            
                                                                                                               
   
                                 	      	            )            	                                                         
                                                      -                              p   I         _   [               M                                                                                                                                                                            (                                                                                                                                                                                                                                                                                                       	                                                                                       "                
                                       
 
           	  	    )    	                   
                  -          p I   _ [     M   iÙ  jÕ  jï  k  nå  s)  yóâ
zëœÜÝo§R™	´
Ôív$6Üó‰ì4	) ¯@¯á’«!f,¦í  ÌÃ	f<
<
z�ö>	� ,¦ÆíJb)‰’·ÀÁÙB]{ö>	q	À	Æ	¾
)´º/S‚�:ŽÑC| ‹\
Ðyy‰ÓyÐry—‰Ðy‰yyy*
A~†%ŒuÜ$	/˜Ätuu/
!.BG:càÍ&t7‘ ™*üÐ	åÙ*
}l'
,
û›ô5¬Ôk&:ø	Q†Ù“$L—ž'1juÐ’e
sl©s:ÄÌ
ï
Z[0ÞfÏÕoä�o
¤¿s] –¤GJú#8Q†Ù“Ì
ŠÙ¦$jÂ × …y:øNÔ)IN)IÎ
ÚÞ ;±.i9û	v]ÙÚ“
ð
N)Iy°ÚÏó¢6›êÁ&Ì
¯½ûC	^ÿ�åÙì.
¾�
þ‡	»INþ
ÜNVÌ
–5©s˜åx±Ú:£¯Äß'	Ì
ï
2YZ¸á´ àëã„T~–úýPÑ*ëû@ŠœÃáót„¬­2Û#	ž	Á	û	
p}´eì
âu±¯Ä¾z�„ÁÜÞZè	>�o
¯ä,	“ÁïÅD�o
½eý’@ž	}¬ yÙ°ÚÏó¢“
ð
:ø6NÔ)IáÑ—@áóž	û	}š£*üV ,íY]�¹½KY„èû0	C	a
ö8>Z^‡‹ÁÜC`Í#Huü@ž	}½ûC	^*)
xnö’�óÿÿ5® ‚5e÷ëC%a?3
dáÍáÎÒn´n	ƒ	�	˜	\î'yJú #àëã8æ.	¬zw –ýE	ÁÆ ž'mÆ ŸñÍL]è0—žN3)'I¬ áBÔÜ	1
Þ
#v®Ú4UšPýƒåG—áäÑ0: Â ÌÒŠ@ �„ÁÜŠèí5bh]À	”	‹Îþ
í5bž'jÎT~„–ú°y â
~“Y¼ô ±"Ul[e.‰è,'Ô)
A
xnö’óÿ-€oÇçKž Ð>Q
ç–­·ã1òœÃu…­3Ü	$	O/¨µ…ÎP5
Ñ¦ <Œ7¥

4]º=!dµÇj«®yÁ/· +ìÏùæxÚÛóÑ¸ö

Ð
pÕ�D£DÇáhY‡ùÜJÏùxÑö7
4=!«®y/¦ <Œ¥
]ºdµÇjÁ}ös	¡—².M¢äY
Âgú³
 ¦ <‰Œ�!7Æ	q
¥
°

4]´·º¦/=¯!dµÇÊ@Ûj«®yÁ/Žs1òœÃu…­3Ü	$	

Ð
pOÕ/¨µ�D£ dÿG	ï/B@l…= G¬Ç­
¬„W-¾%A�
Y§´e( ÿ‹°ˆ	L)¼2]¡Æ;
ãt	z/N Ú'½cK ÅpÝÓ	dy¸Vj×¬|Ø 	`	"œãõ„aøFG»'›î5AD K ’ Ú8hÅpÝÓ	d'½cŒb¿T½%ƒ$EHa?¬¦³3ÝŠÙz¹§-GîçZb	w	D$Ohò}‹ rCÞÌÑ3²8l¦Ëo°û‡‰#?et‰�y�—&) }Û loÜ²Ò	'
,
ª
cÈ„Ò3¶=û~¦þ(oHR³ú0ñ7Sh1 ²]¤à(	
Ž2Z¼=â¯î/
mÊ³0<Fx.y¸,D�Ébˆ ñ¯*ü›j`›öé7¤Ñ‡rCÞÌ3l°‰³<Fx�b‹ ²8¦Ëoû ‰�!Æ	q
°
´·¦/¯Ê@ÛŽs%Œƒ$bEHa?¬¦³¿T½3† ù
¹mü ´x§�+PU ­ Ã  4¬;[ñz|B„Î» .:HïÓoŠ�µè@[c	o	x	„	Ž	™	Ç	r
±
§Ô0­°ÞEŸA]Üïh]Í(ºtJkèÊâ!$O´·Ïhò}‡ÊÑæÖfçŽ×	 ³ ²Ë#Vótþmd Xnz;Èî•–Ö	

6 #¨®Ä#cÙ»CDJ®íT ¤ 	5OWÅ
Í
2<Z\@ð:{—¸Æ	m…k¼Ø ^†›ÕøTü	j¦ªýL€Foí*
/
B
yÇ!oç÷K“ž¦ô i¾Ðþ 5.6>¸ +ì;Žç(ˆÛô‚¿	Å	ù	p
¥Àt"-?ñ¸�…
n
»
Ñ
í
pÊÂÕÝúãv�NßD²¤… A¾üD	Ÿ	L
¥_~˜ü�»âÍ×%IÒ& d t ¸ +4ì0X\nz;Ž’ç(6;fˆ±ÈÛñÐØîô‡•£ô‚–ß'	¢	¿	Å	Ö	í	ù	ÿ	

p
�
‰
¤
½
6\¨¹Ì7AR¥ÀÄé Äß#¨®Äø#ctÆÙ"-?Y»CHa°ñü'D¬¸áûÿJ¤®í … ¿ þ 	aiÁÃúAJ'^¾Õlóü;	D	\	Ÿ	·	
L
Œ
¥¾_~˜à¸ü'�˜»ÁòUžÏâ*,.~¡Í×%+8I‹ÂŸÒÞER^‡Ú+”ù~ì#AüÐpå%ƒ Ÿcõþ=	F	¹	
`
ÿ
®¼ dfOtÃÞ6*J( 5 º 1òÿ‹°âv�œ°ÃÖÝ*u…˜­»	3ìL…ýÜå	$	-	ˆ	Ý	
n
»
Ñ
è
í
ô
p~‘ÊÑ?OˆÂ“ÕÝíÌúLXa$/d¨µÍØãêv�)N†¼ßåùý2D]²¤M!2ó.Z¿î -9�”�Ä	&3v†®4…—ºÂð…BÝé	%	1	
9
f
n
‘
»
È
Ñ
í
ZpvÊ$3P¯ÂÆÛpÕÝá úÿ0I˜©¶ãEv�¨µ¼N`¶ßD‚²f¤VeÄ^ € ë :—õ`¥°´	N	ª	HÕæ1
<;
=@Q€Šé§¸óÈÊ	Ð	ê£¥À+ùD üÊêØ[¦ß½	Ã	è	ë	÷	?

l„‡ËX©# a ß <ekºâ*Œ�¨²/jÓO:aÎE d R^‡Ú	+”ýXnz�ËÑ	auù;JÈ9vî~•Çì#–	Ö	

g
ç
6A‰Ðü ’¾#¢¨®Ä#WcÙˆ»é!4CÌ/DÐû]Jp®íå %6ÏõÊ>Úò¸w¤Ÿx(  Û     è  X         X7»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÞKÒ �k¹	»�»Òø�p@Ý9ôïò ƒ¾6aDëø†Õ6àà@‹ý[¶Ÿ¾£»»º»þô#Óîóð�ÿ·þ#Ü<8¾ `Ž¾-Õ·hô¯_á;�|AŽ? p4D?Å>#àøA4“ŽˆM÷}K"·H9JóÿÐþß¾àú<ø¿ã�>.>=¾8ø>þ¸ûò>xNÝ+±.DÊ•üá´û#ë’�On(¨ÿ¿ò>¾‡ø#Þýâú¾YVV�³h¸I¶¹®  ÐtÔ A u“Cc€Â¹ƒ®ÁQ}8¹ &ÿs?‰0Í¥3‚
s4È|çz=3ù3ó¾¬êëúú»=ÊÏ¯òÔîVÀþ¤
ñ©#©Ã~ÇýUz@†
Ü’Û?†G
«?¨r�/rº–Hè¯W�uÞ×ù»šê†¦P£Æ¬>h)Ua8j]U©s–¸�b"Ò�"KýÿM˜Õ66íi-5ô"KýÿM˜Õ66íi-5öKóþ^óöüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóî>á9¯E$„ê¨ù¨ÕS¿:&oj°nQl«6Q�£sB»ÃÎ€�æ°æuÑÖÃŽá�<ŠðâÓ4?
ê¢Ô|~/þ�Ó0æÈ8=Ç+èÍ8ŽÇ(·…0ƒŽhR<A»âÛ·èï�Romƒ†5Œ0ãg:ÃŸ�ÚÇßSÛ6ÄÄÜžÁ�O¢ÆÐa¸Q6ÐÌôñx¬ô;PÌØüpÄ²È`Æ>:<Y¶`óªàklxƒÃ€ˆ0|æÐvL çò£… Ã‡Î¾Èêp›<ïÆ³LÛ>¹³ë¡Ä®¸L¸±X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Âª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plnüoù‚  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  p<?xml version="1.0"?><Features nextValidID="13"><Feature recentID="12" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5808-5912" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3619-3740" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2435-2570" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1543-1767" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2255-2584" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1813-2241" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4191-4776" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2651-3445" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5738" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4947-5738" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5739-5807" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="MIR23A" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="925-1499" color="#a6acb3" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>ff78c584-a3e1-4c98-ae91-a20e1b04a45a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="2:20:12">2023.4.13</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  i<StrandColors><TopStrand><ColorRange range="0..2182" colors="black"/><ColorRange range="2183..2184" colors="magenta"/><ColorRange range="2185..5975" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..2182" colors="black"/><ColorRange range="2183..2184" colors="magenta"/><ColorRange range="2185..5975" colors="black"/></BottomStrand></StrandColors>  Ž      _  4         47»IÖã¸cÍ’”ô›Žþ:"(³„’3U©NuÔ5‡ÇZ6[Ž�)ª3Ž³œFg2‡hi¡ä¦–ImiÀ-¤­“öf¯2�—§	X?>?\óö‡-e‡&+öIsÖ@z½¡ËXjp•ã÷ ÒvÔ‰¶cÔœÿæ‡-aÂVÏƒi�Òv¦êùè4�¹É¤¶Îiöc
 ÒvÖ dÂ¡íÀ½K½ÿhrÖ**ƒ}V×êõX²]{Ïö‡5`0�Èœ ¹™M»ƒ—‘÷Žž›¥œ{y�ýNL©^”è'ÄìÞKÒ �k�½7H0ó±.DÊ•üá´û#ë’�On(¨ÿ¿ò>¾‡ø#Þýâú¾YVV�³h¸I¶¹®  ÐtÔ A u“Cc€Â¹ƒ®ÁQ}8¹ &ÿs?‰0Í¥3‚
s4È|çz=3ù3ó¾¬êëúú»=ÊÏ¯òÔîVÀþ¤
ñ©#©Ã~ÇýUz@†
Ü’Û?†G
«?¨r�/rº–Hè¯W�uÞ×ù»šê†¦P£Æ¬>h)Ua8j]U©s–¸�b"Ò�"KýÿM˜Õ66íi-5ô"KýÿM˜Õ66íi-5öKóþ^óöüÿ—¼ý+ÏÚï?Ø8yjªš˜Ñóî>á9¯E$„ê¨ù¨ÕS¿:&oj°nQl«6Q�£sB»ÃÎ€�æ°æuÑÖÃŽá�<ŠðâÓ4?
ê¢Ô|~/þ�Ó0æÈ8=Ç+èÍ8ŽÇ(·…0ƒŽhR<A»âÛ·èï�Romƒ†5Œ0ãg:ÃŸ�ÚÇßSÛ6ÄÄÜžÁ�O¢ÆÐa¸Q6ÐÌôñx¬ô;PÌØüpÄ²È`Æ>:<Y¶`óªàklxƒÃ€ˆ0|æÐvL çò£… Ã‡Î¾Èêp›<ïÆ³LÛ>¹³ë¡Ä®¸L¸±X|}LsõøöÜF¬kß<úæ
¬Ê¯ÏïLÀ¶8ºÏßõè©£N™`§VTÖM·V­Õ•6ª­ãk’ˆ*/W¶Ö&é¶.&|±û“‘:–Ø-“Š¾"¢›ÎÝkÝ×gÁM•"Tø>XHN^Ý¥£(ÎÞ?:½,~,�N6–Ã×3 D0¨É 3ºó¯³·‡³Œì,¬8Ã	´ííPÂYÂ›ÝÐ\ÐT]ˆMT=5PôÉU2Žª½�ï?þM·Ulsµ-ƒüteF}«ÿ�NþÈÎïŠñþ<éðgâóêïëLƒ:»díÎ$&í+�²³½Nˆ�Åÿò´ü|ã>›Â^lºõü%Ç¦Ïx4ÓÞ	tM˜�Â9Ñ+¡H ùyÃ�äQtš‚n3¸áOJ~°UD “ºÃWWß8$Âª¢£SMs4UTµo¨n«œáÎÒÅ^Ü¥ªamUë~Fú¥iU…*•µ¹Rfa%z‡J}c¥´„7æí1¸¹«+od£áïòÈ‘—œg§Ûƒý#�aŸ1ÜíðïF¦ÓY_OOÄÍ‚ø×©¼ûÛÒæ–Š<9RJÏJY*3\¢�hçCl‚-ÎË*	ƒ­­;Â¿\mC�†ÿØ¢5U0¤ï¬/¼l¢ÑIJ4Šmí‚˜4Þ6Zîž-�o%ê¸‡‚{_RÚáH˜ÃŽèü2ÖpgÌ÷dÑz•Hí¶�W+¬{µéóŠ½+—÷²7õáºÓn©êßL«€„Õ]V<ÕT”wb…žÙî¾ªÖi¡M©´
h»a0gf¡bjEVWV@+ÌÝ«üU#ß‡,plnüoù‚  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  ¬<?xml version="1.0"?><Features recycledIDs="12" nextValidID="13"><Feature recentID="11" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5190" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4399-5190" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5191-5259" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="NeoR/KanR" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2103-2897" color="#ccffcc" type="standard" translated="1"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3643-4228" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="8" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1265-1693" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="7" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1707-2036" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="995-1219" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1887-2022" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="2" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3071-3192" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="1" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5260-5364" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  @<Notes>
<UUID>ff78c584-a3e1-4c98-ae91-a20e1b04a45a</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="8:48:36">2023.4.12</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  i<StrandColors><TopStrand><ColorRange range="0..1634" colors="black"/><ColorRange range="1635..1636" colors="magenta"/><ColorRange range="1637..5427" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..1634" colors="black"/><ColorRange range="1635..1636" colors="magenta"/><ColorRange range="1637..5427" colors="black"/></BottomStrand></StrandColors>  $ý7zXZ  æÖ´F !   t/å£à+ã] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÉ;_x�ïÕwP	îuåóýÄˆ{=iÿ»ŸÀæðµÚ|r6WÄ·6QKq]4êNÎóC­„O{ð©�ÜÊ”pòã%âÈç>F~zï�a¹<‘Áù€d�‡îûXÏå±Âo˜ŒKN÷Žú¯Õ]ëƒqƒ@õ�˜í¾ˆyêWîr˜ÓL¸hôL#ÎERÐFóÿ,±ŽyÆ�’|º»P«Êa²¥¥V�ÜEvóæÈúúÒìf»'ef÷>0ZHÓc�~L4Î„è½P¥¶Ÿód´%Ýøª �‡ÜŠã8}’Y~ÍFwÞÍîÆSÊ*àÆbQòXxóÒL¾_ÙfÛ?Ì‚�¢ou¡¯ëFj(×exùº¨ò/‹|a™ÐíäòÉ´h`zÀHTr.j¨ÐZg‰—æ¬ìBqÑóy¥O9©�òÆE	�=p�¹©^ °ïBR‚°VwmÂxlº.ŒX¢¡zÍw¬ÕðÍ‘¶—¤œ8á¼9g/ýó7OñôJõ<^_ 2âÐØGËcì8õS^c>NâùLhºögãLõ‹2>�ÅÃmàvå‹8ÕŒ¹¥˜+\I�ÁKcš¡mŒ‘ç/mbÛy¤ bÎl§{Ý�[0“ñ„s#±0&×�Ñ?/º=ÇÕw¤‘€v×tYO®¹wŽÁz`w(ñú r»(qâÃ¸óš›úœuZn’ë±a�‰ï�µ¹©ºòF‚/i£†¼�±`Dd«syÚ1-ŽæÂ^ØyH­ÁÔ>ú’yýH=�Oä—é –â×Õ †X«lÚô^š8<Ãl¡ÁygÓ©E2ÿ4ôLñƒï×“V¼ =ö˜Ihã/”Î˜¹lQŠ”QßÛød	ù|³ã_*ëçcI¤
-æ¬‹;ŽS+²‘9~|_ ÜUjA§ãV¯ÐØòˆ¼èØ-%ÄSÞâ^žÃhˆo6�¯âÓXcwŠ�`à‚³ÉîáÙÆet"kºCñp/îëÔ-8r»ùÈ¼w<{Û™ú[‡Ô™³ c¿˜[«Ku¬Rž={Î•óÝZµû€”rý€ÃCÏH~®î½v†	Vˆ¨‡¼é*£íK‹�‹Z$wÍ¡!:Éæzb];8p»$GÀµôÿ²s™”BðJ÷wú�xeAq?@§·È¦ppœ6ƒÎ©ÔÃ­.î‰·ã¨y�²TËBoÕîÐt¦ù  ©�¨QhVúXk2s�'k¶ü^N­øË€U)™çƒ
Š—þ¸&=Ñj°²WœçmjU qÜ;*+Zw.ÀE7eÿmƒBHÄ"R[¿0¼üª¾ØßðˆÅÖÉÇƒ>6)®Ô-—õ…˜a²inÿ)€1v§	,PË•¾ê&.C„„ë®6dªêWÞ’ð
Á{°ÿ¯7?°é0ŠÏ™œì\ˆŽ®§VLLH9›‘È 32Ñ4“îQ”Zê…~”`é.H0¤œ+AÜ(¥™ ò—÷Isalã±Ù~óæ€!ÌÐE¤Çæ~bf³Ø¬�vñOÉI)ñ?7Q`¸ ö¼ÊÞ‘Ž¯Fjy�_c•¯àl©ùºlçþ \HªyR4t	¬½~.ØOçÛzân>_›ÊâKìÎU§Ùìo«JT—ð-•nè&…›ß˜£¦n‡ðüþE®¬mkfÍƒš«át2)ƒ\§GF$þ£ñë’ó9q‘{6¢}ÐÃi7§.úÝJ[h˜¯P¦Ð„SSì¶íÅ 3.Ìi$W‹1]Ò"ä³ÚqI`Û8¼ þ‹.'¯#k æóûÂ• Âò�}ê€Úß¹êÃi”ËÑ®NFmàvx½QD=SE/TßTñ:�—¦ô%ó§M>Ùúšˆ»Xòn‰%&&Ž‘šR þ§0éaF˜”ó.KªbÝgÑÏEÖMÔsºðÑñ!Œ„°®åNÔ¼ÒÎÚ
èZvIõp1û�ÒÓEíP’±ž;"…7èªË´CÆdÝi¼^ä´©ÛÌÇÎ¨2ûq`n'Ç:îÙvi7†°P2<ÊùD�ãÀàšë7 %ï–0bâ›ÆÜ|	Ôxæc6®1º‰Z˜Ðp ÀÓ«Gk3Vú0Çµâ{Ü‰¯áKéÝ&'päB]!j�’XN–¨�!Ä©Æ÷ÁH½ó:'Þ§—svÀ vY™³Í’Pdmpc úŒ¥½‹Ñ@¥¦<Ö¾™<×ËýÏi ›ôõ#¸÷¢Ã’9ÁÙbãmuˆÇÕïÄó   Ó—w,;}× ÿˆV  vwÝŸ±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  å<?xml version="1.0"?><Features nextValidID="13"><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5725" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4934-5725" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5726-5794" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="1" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2638-3432" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="2" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4178-4763" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1800-2228" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="202-581" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2242-2571" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="bGH" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1530-1754" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="582-785" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2422-2557" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3606-3727" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5795-5899" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="T7" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="830-848" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="Mir23a" type="misc_feature" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="925-1486" color="#a6acb3" type="standard"/></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  Ÿ<Notes>
<UUID>2eff4382-0531-4f0e-a2e1-b4c55ca33154</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-Mir23a(rat)-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="7:53:3">2018.3.15</Created>
<LastModified UTC="5:28:27">2025.9.20</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y      K         
?????                                                                                                       ÿ d      DO  d              E              ÿÿÿÿYô? P                                                                                                                                                              ©<StrandColors><TopStrand><ColorRange range="0..5962" colors="black"/></TopStrand><BottomStrand><ColorRange range="0..5962" colors="black"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
